AKOS BBS-00004561
4-CHLORO-QUINAZOLINE
CAS: 5190-68-1
Molecular Formula: C8H5ClN2
AKOS BBS-00004561 - Names and Identifiers
| Name | 4-CHLORO-QUINAZOLINE |
| Synonyms | AKOS BBS-00004561 4-Chloroquinozoline 4-CHLORO-QUINAZOLINE Quinazoline, 4-chloro- |
| CAS | 5190-68-1 |
AKOS BBS-00004561 - Physico-chemical Properties
| Molecular Formula | C8H5ClN2 |
| Molar Mass | 164.59 |
| Density | 1.349±0.06 g/cm3(Predicted) |
| Melting Point | 96-100 °C |
| Boling Point | 281.0±13.0 °C(Predicted) |
| Appearance | White to yellow solid |
| pKa | 0.83±0.30(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00228682 |
| Physical and Chemical Properties | Chemical properties The crude product of this product is yellow solid, pure product is white needle crystal, m.p.97 ~ 98 ℃, insoluble in water, soluble in chloroform, carbon tetrachloride and other solvents. |
| Use | Use 4-chloroquinazoline is an intermediate of the acaricide quinite ether. |
AKOS BBS-00004561 - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
AKOS BBS-00004561 - Upstream Downstream Industry
| Raw Materials | Ammonium hydroxide Phosphorus pentachloride Anthranilic acid Quinazoline 4-Hydroxyquinazoline |
| Downstream Products | 4-(P-HYDROXYANILINO)QUINAZOLINE QUINAZOLIN-4-YLAMINE |
AKOS BBS-00004561 - Production method
1. Heat and cyclize anthranilic acid and formamide to generate quinazolidone -4, and then chlorinate phosphorus pentachloride and phosphorus oxychloride to obtain the product.
2. The preparation method is to add 4-(3H) quinazoline, phosphorus pentachloride and phosphorus oxychloride into a four-mouth flask, heat and reflux for 2 hours, after the reaction, evaporate POCl3 under reduced pressure, dissolve the solid residue with chloroform, pour it into the ice-water mixture, and add 36% ammonia water dropwise under stirring at the same time to keep the pH value of the mixed solution at 6-8.
Last Update：2024-04-10 22:29:15
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CAS: 5190-68-1
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Product Name: 4-Chloroquinazoline Visit Supplier Webpage Request for quotation
CAS: 5190-68-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 5190-68-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Raw Materials for AKOS BBS-00004561
Downstream Products for AKOS BBS-00004561